Biomarker

  • Biomarker-basierte Diagnose rapid progressiver Demenzen - Optimierung diagnostischer Protokolle (Demtest) BMBF 2012-2014
  • Protecting the food chain from prions (Priority) EU 2009-2013
  • Development of a blood screening assay for diagnosis of prion diseases in humans (prionscreen) EU 2007-2010
  • NoE:NeuroNe (Molecular mechanisms of neuronal degeneration: from cell biology to the clinic) EU 2005-2009
  • NoE:Neuroprion (Prevention, control and management of prion diseases) EU 2004-2009
  • Early clinical diagnosis of human spongiform encephalopathies by analysis of biological fluids (CJD Markers) EU 2003-2005
  • Small Interspersed Nuclear Elements (SINEs) als prädisponierender genomischer Faktor und Kofaktor für eine TSE von Tier und Mensch DFG 2002-2005
  • Cerebrospinal fluid investigations as model to study neurodegenerative disorders in humans (CMPB) DFG 2002-2004
  • Biomarker development in pron diseases BMBF 2001-2004
  • Laboratory supported diagnosis of Creutzfeldt-Jakob disease (CJDtest) EU 1998-2001
  • TSE biobank BMBF 2001-2006
  • WHO reference center for CSF tests in prion diseases since 2000
  • Stadiumabhängige biochemische, klinische und bildgebende Charakterisierung der Demenz vom Alzheimer Typ und der Vaskukären Demenz BMBF 2013-2015
  • Brain imaging as an aid to determine molecular subtype in prion diseases BMBF 2008-2009
  • Quantitative analysis of MR scans in Creutzfeldt-Jakob disease (QAMRIC) EU 1998-2001
  • DaTSCAN in subjects with extrapyramidal syndromes GE Healthcare 2009-2012
  • PDT301-An open-label phase 3 clinical study to assess the striatal uptake of an intravenous solution containing the dopamine transporter radio-ligand, DaTSCAN, in subjects with DLB Amersham Buchler/GE Healthcare 2002-2006

Epidemiologie

  • Klinische und molekulare Charakterisierung rapid progressiver Alzheimer Erkrankung (rpAD) BMBF 2012-2015
  • Nationales Referenzzentrum für transmissible spongiforme Enzephalopathien BMGS/RKI 2006-2018
  • Netzwerk "Infektionen des Nervensystems" RKI 2009-2010
  • CJK-Netz (Forschungsnetz zur Verbesserung der Früh- und Differentialdiagnose der CJK und rasch progressiver Demenzen) BMBF 2003-2006
  • CJD Surveillance in Central and Eastern EU-countries and China (SEEC CJD) EU 2002-2004
  • Creutzfeldt-Jakob disease: epidemiology, risk factors and diagnostic tests (EUROCJD) 1993-2010
  • Untersuchungen zur Epidemiologie und Frühdiagnose humaner spongiformer Enzephalopathien BMGS 1996-2006
  • HTSEs: The neuropathology network (Prionet) EU 2000-2003

Therapie

  • A randomized, double-blind study versus placebo for the evaluation of the efficacy of doxycycline administered by oral route in patients affected by sporadic Creutzfeldt-Jakob disease. BMBF 2009-2013
  • NoE Neuroprion: The 37 kDa laminin recepor and the membrane bound PrPc as targets in TSE therapy EU 2004-2009
  • A randomized double blind placebo controlled trial on long term treatment of Galantamine in mild to moderately severe Alzheimer´s disease Janssen-Cilag 2008-2012
  • Rivastigmine in MS Novartis 2009-2013