Diagnostic criteria for iatrogenic TSE

Definite:

  • Definite CJD associated with a known risk factor for iatrogenic disease (see list)


Probable:

  • Progressive cerebellar syndrome in recipients of (growth) hormones extracted from human pituitary glands
  • Probable CJD associated with a known risk factor for iatrogenic disease (see list)


Risk factors for iatrogenic CJD:

  • Treatment with (growth) hormones extracted from human pituitary glands, or after dura mater transplantation
  • Corneal transplantation in cases were the donor was diagnosed with definite or probable prion disease
  • Neurosurgical instruments that were previously used in patients with definite or probable prion disease