Characteristic EEG changes in sporadic CJD are periodic bi- and triphasic waves (periodic sharp wave complexes, PSWCs).
EEG criteria used in the diagnosis of CJD
- Periodc "sharp-wave" complexes (PSWCs)
- Periodicity (most important criterion)
- Frequency 0.5-2/sec
- Duration between 100 und 600 msec
- Amplitude higher than 150 μV-300 μV
- Generalized activity, with a maximum over the frontal region, partly also lateralized
- Sometimes followed by burst suppression"