The basic cerebrospinal fluid (CSF) parameters (cell count, CSF/ serum albumin ratio, glucose, lactate, immunoglobulin ratio, oligoclonal bands) are normal in CJD patients.
Detection of brain-derived proteins in CSF helps in the differential diagnosis. Currently, the detection of 14-3-3 proteins in CSF is the most important test.
(Cramm und Schmitz et al. Characteristic CSF Prion Seeding Efficiency in Humans with Prion Diseases. Mol Neurobiol 2014)